Omeprazole: Indications

Thanks to the pronounced acid inhibiting effect, duodenal ulcers heal faster with omeprazole than with H2-blockers such as cimetidine or ranitidine. Already after two weeks of treatment, healing can be demonstrated endoscopically in 50 to 70% of the patients. The effect of omeprazole on gastric ulcers is at least as beneficial as with H2-blockers, but a longer treatment is necessary. Omeprazole can also have advantageous effects on cases that are resistant to other therapies.

A helicobacter infection can often be observed in association with duodenal ulcers. Combined with antibiotics (e.g. highly dosed amoxicillin) omeprazole can cause the eradication of helicobacter and can thus heal it in the long run.

Omeprazole is superior to H2-blockers against esophageal reflux disease. However, to avoid relapses a chronic omeprazole treatment is necessary. Omeprazole is furthermore the drug of choice for long-term treatment of Zollinger-Ellison syndrome.

The benefits of an intravenous omeprazole treatment for acute gastrointestinal bleedings are not satisfactorily demonstrated.

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