Digoxin: Pharmacology

Digoxin, produced half-synthetically from Digitalis lanata, leads to increased myocardial contraction (positive inotropic effect) and thus to more performant pumping. This effect is based primarily on the greater free intracellular calcium concentration of the myocardial cell. Digoxin causes complex electrophysiological effects (directly or through vagal stimulation): myocardial automaticity is increased, transportation in the atria and in the atrioventricular node are reduced, and heart rate is decreased.

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