Haloperidol: Pharmacology

Haloperidol, a butyrophenone, apparently owes its antipsychotic effect primarily to its antagonistic activity on dopamine D2-receptors in the central nervous system. Compared to other neuroleptic agent it has a relatively mild sedative effect but it often causes extrapyramidal symptoms. It has an antiemetic effect through its activity in the 'chemoreceptor trigger zone'. Antagonistic effects on other receptors (e.g. histamine or serotonin receptors) have marginal importance.

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