Metformin: Pharmacology

Metformin, an antidiabetic biguanide, apparently primarily owes its antihyperglycemic action to an effect on the glucose transport through the cell membrane. It thus increases the glucose uptake in the muscle and fat cells. In addition to this, inhibition of the intestinal glucose absorption and of the hepatic gluconeogenesis probably plays a role. Metformin has no influence on the secretion of insulin; however, its effect seems to be dependent on the circulation of small amounts of insulin in the blood. Metformin also has lipid-lowering and hypotensive effects and it can inhibit the platelet aggregation.

Table of Contents | Indications | Adverse Reactions & Interactions | Contraindications & Cautions | Risk Groups | References