Metronidazole: Indications

Metronidazole is the drug of choice for symtopmatic intestinal and extraintestinal amebiasis as well as infections with Trichomonas vaginalis and Giardia lamblia. It is quickly and reliably effective against Gardnerella vaginosis.

Anaerobic infections (e.g. cerebral abscesses, intra-abdominal abscesses, gynecological infections of the pelvic organs, soft tissue infections, osteomyelitis) are well documented indications. Metronidazole also has an advantageous effect on parodontopathy. Anaerobic infections of the lower respiratory tract respond better to penicillin or clindamycin. Metronidazole is combined with a second antibiotic for the treatment of mixed infections with aerobic germs and for pre-operative infection prophylaxis (colorectal and gynecological interventions). It can be an alternative to vancomycin in the treatment of mucous colitis. Imidazoles are also used against Helicobacter pylori in which case one has to expect resistant germs. Metronidazole is sometimes more efficient than sulfasalazine for Crohn's disease, however, the tolerance of long-term administration is not established.

Applied topically, metronidazole has proven effective against rosacea, acne, and foul-smelling skin lesions (tumours, decubitus ulcer).

Table of Contents | Pharmacology | Adverse Reactions & Interactions | Contraindications & Cautions | Risk Groups | References