| Theophylline: Risk Groups
Can be given. At the end of pregnancy: inhibits labour; tachycardia and increased excitability and vomiting possible in the neonate.
About 70% of the maternal plasma concentration is reached in breast milk. Can be given nevertheless (but in low doses if possible).
Short half-life (except
neonates)! If possible use slow release preparations (adequate
for chidren) in long-term treatment. Dose: neonates (4 weeks and younger):
1-2 mg/kg twice daily; older neonates 1-3 mg/kg 1 to 3 times daily;
children older than 1 year 16-20 mg/kg/day.
of the dose and monitoring of plasma levels may be indicated. Particular
caution with pulmonary edema, heart failure or reduced liver functions!
No dose reduction necessary.
of half-life (up to 30 hours) is significant with cirrhosis and moderate
with other hepatic diseases. Reduce dose and establish plasma
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