Atenolol: Adverse Reactions

Pronounced fatigue and cold extremities have been observed in 10 to 20% of the treated subjects. Complaints about bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, atenolol can cause bronchospasms in asthma patients.

Amongst the many but rarely observed side-effects are sleep disturbances, depressions, paresthesiae, impotence, exanthema, psoriasis exacerbations and arthropathies. Clinically relevant changes in the blood sugar have hardly occurred. There is no clarity as to the practical significance of the above mentioned changes in the lipid metabolism.

Atenolol: Interactions

Verapamil and atenolol both reduce myocardial contractility; intravenous administration is permitted at the earliest 24 hours after the withdrawal of either drug (danger of acute heart failure!). The same is true for class I anti-arrhythmic drugs (e.g. quinidine). The effect of atenolol on blood pressure is reduced by anti-inflammatory agents.

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