| Dexamethasone: Indications
Dexamethasone can be used for all conventional indications for glucocorticoids.
There is special documentation available for the following uses: dexamethasone
produces considerable pressure relief in the event of cerebral edema
(e.g. following a tumour) or raised intracranial pressure of a different
origin. It is also very efficient as an antiemetic agent in strongly
emetogenic chemotherapy; it is thereby often combined with other antiemetic
agents (e.g. ondansetron). It is also frequently used in context with
different forms of shock, even though its use is sometimes viewed
controversially (e.g. septic shock). However, its effect for the initial
treatment of bacterial meningitis is well documented. Its administration
before birth can reduce the incidence of respiratory distress syndrome
in premature infants; it is also helpful for bronchopulmonary dysplasia
after respiratory distress syndrome. Other indications are: acute mountain
sickness (high altitude disease), anaphylactic reaction, angioneurotic
edema, collagen disease, etc. It is used topically on the eye after
cataract operations, on the skin for eczema and psoriasis, as well as
intra-articularly for arthritis and osteoarthritis.
The dexamethasone suppression test (DST) is used for the differential
diagnosis of Cushing's syndrome and, although controversial, for depressive
The dexamethasone suppression test (DST) is used for the differential diagnosis of Cushing's syndrome and, although controversial, for depressive diseases.